1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine

Base Information

• Chemical Name: 1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine
• CAS No.: 957873-00-6
• Molecular Formula: C₁₆H₁₇IN₂O
• Molecular Weight: 380.228
• Mol file: 957873-00-6.mol

Synonyms:1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine

Chemical Property of 1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine

There total 1 articles about 1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

3-(3-chloropropyl)-2-fluoro-4-iodopyridine (945600-05-5) + 4-methoxy-benzylamine (2393-23-9) → 1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine (957873-00-6)

Guidance literature:

With pyridine; potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

DOI:10.1016/j.tetlet.2007.08.076

Reference yield: 93.0%

1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine (957873-00-6) + benzyl alcohol (100-51-6,185532-71-2) → 1-(4-methoxybenzyl)-5-(benzyloxy)-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:

With copper(l) iodide; caesium carbonate; In toluene; at 110 ℃; for 72h;

DOI:10.1016/j.tetlet.2007.08.076

Reference yield: 92.0%

morpholine (110-91-8,99108-56-2) + 1-(4-methoxybenzyl)-5-iodo-1,2,3,4-tetrahydro-1,8-naphthyridine (957873-00-6) → 1-(4-methoxybenzyl)-5-morpholino-1,2,3,4-tetrahydro-1,8-naphthyridine

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 120 ℃; for 30h;

DOI:10.1016/j.tetlet.2007.08.076

upstream raw materials:

3-(3-chloropropyl)-2-fluoro-4-iodopyridine

4-methoxy-benzylamine