Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-fluoro-, (1R,2R,4R)- (9CI)

Base Information

Chemical Name:Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-fluoro-, (1R,2R,4R)- (9CI)
CAS No.:211444-72-3
Molecular Formula:C₈H₉FO₂
Molecular Weight:156.157
Hs Code.:
Mol file:211444-72-3.mol

Synonyms:Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-fluoro-, (1R,2R,4R)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-fluoro-, (1R,2R,4R)- (9CI)

Chemical Property:

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Technology Process of Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-fluoro-, (1R,2R,4R)- (9CI)

There total 3 articles about Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 2-fluoro-, (1R,2R,4R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 211444-62-1
benzyl (1S,2S,4S)-2-fluorobicyclo[2.2.1]hept-5-ene-2-carboxylate

: 211444-70-1,211444-72-3
(1S,2S,4S)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1016/S0957-4166(98)00195-5

Reference yield:

: 211448-04-3
4-(1R,2S,5R,3'S,4'S,6'S)-[5-methyl-2-(1-methyl-1-phenylethyl)-cyclohexyloxycarbonyl]-4-fluorobicyclo[2.2.1]heptene

: 211444-70-1,211444-72-3
(1S,2S,4S)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 72h;
DOI:10.1016/S0040-4020(99)00785-1

Reference yield:

: 211444-56-3
(S)-4-Benzyl-3-((1S,2S,4S)-2-fluoro-bicyclo[2.2.1]hept-5-ene-2-carbonyl)-oxazolidin-2-one

: 211444-70-1,211444-72-3
(1S,2S,4S)-2-Fluoro-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / tetrahydrofuran / 4 h / 0 - 20 °C

2: 75 percent / 1 N NaOH / tetrahydrofuran / 4 h / Ambient temperature

With sodium hydroxide; In tetrahydrofuran;
DOI:10.1016/S0957-4166(98)00195-5