9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

Base Information

Chemical Name:9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile
CAS No.:1425945-87-4
Molecular Formula:C₁₆H₇ClFN₅S
Molecular Weight:355.782
Hs Code.:

Synonyms:9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

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Chemical Property of 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

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Technology Process of 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

There total 8 articles about 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 367-21-5
3-chloro-4-fluorophenylamine

: 1425945-86-3
(E)-N'-(2,7-dicyanobenzo[d]thiazol-6-yl)-N,N-dimethylformimidamide

: 1425945-87-4
9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

Guidance literature:: With acetic acid; at 118 ℃; Microwave irradiation;

Reference yield:

: 1425945-82-9
tert-butyl 4-amino-3-bromo-2-cyanophenylcarbamate

: 1425945-87-4
9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: acetic acid / 2 h / 118 °C / Microwave irradiation

3.1: pyridine; copper(l) iodide / 0.33 h / 130 °C / Microwave irradiation

4.1: 0.03 h / 70 °C / Microwave irradiation

5.1: acetic acid / 118 °C / Microwave irradiation

With pyridine; copper(l) iodide; acetic acid; In dichloromethane;

Reference yield:

: 17420-30-3
5-nitroanthranilonitrile

: 1425945-87-4
9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; ammonium formate / ethanol / 0.5 h / 85 °C / Microwave irradiation

3.1: bromine; acetic acid / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C

5.1: acetic acid / 2 h / 118 °C / Microwave irradiation

6.1: pyridine; copper(l) iodide / 0.33 h / 130 °C / Microwave irradiation

7.1: 0.03 h / 70 °C / Microwave irradiation

8.1: acetic acid / 118 °C / Microwave irradiation

With pyridine; dmap; copper(l) iodide; palladium 10% on activated carbon; bromine; ammonium formate; acetic acid; triethylamine; In ethanol; dichloromethane;