methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate

Base Information

Chemical Name:methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate
CAS No.:1425945-34-1
Molecular Formula:C₁₇H₁₁ClFN₅OS
Molecular Weight:387.825
Hs Code.:

Synonyms:methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate

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Chemical Property of methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate

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Technology Process of methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate

There total 9 articles about methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1425945-87-4
9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

: 124-41-4
sodium methylate

: 1425945-34-1
methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate

Guidance literature:: With methanol; at 65 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1425945-82-9
tert-butyl 4-amino-3-bromo-2-cyanophenylcarbamate

: 1425945-34-1
methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: acetic acid / 2 h / 118 °C / Microwave irradiation

3.1: pyridine; copper(l) iodide / 0.33 h / 130 °C / Microwave irradiation

4.1: 0.03 h / 70 °C / Microwave irradiation

5.1: acetic acid / 118 °C / Microwave irradiation

6.1: methanol / 0.5 h / 65 °C / Microwave irradiation

With pyridine; methanol; copper(l) iodide; acetic acid; In dichloromethane;

Reference yield:

: 1425945-81-8
tert-butyl 2-cyano-4-nitrophenylcarbamate

: 1425945-34-1
methyl 9-(3-chloro-4-fluorophenylamino)thiazolo[5,4-f]quinazoline-2-carbimidate

Guidance literature:: Multi-step reaction with 8 steps

1.1: palladium 10% on activated carbon; ammonium formate / ethanol / 0.5 h / 85 °C / Microwave irradiation

2.1: bromine; acetic acid / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

3.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C

4.1: acetic acid / 2 h / 118 °C / Microwave irradiation

5.1: pyridine; copper(l) iodide / 0.33 h / 130 °C / Microwave irradiation

6.1: 0.03 h / 70 °C / Microwave irradiation

7.1: acetic acid / 118 °C / Microwave irradiation

8.1: methanol / 0.5 h / 65 °C / Microwave irradiation

With pyridine; methanol; copper(l) iodide; palladium 10% on activated carbon; bromine; ammonium formate; acetic acid; In ethanol; dichloromethane;