3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Base Information

Chemical Name:3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid
CAS No.:1208330-01-1
Molecular Formula:C₂₂H₂₁ClN₂O₄
Molecular Weight:412.873
Hs Code.:

Synonyms:3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

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Chemical Property of 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

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Technology Process of 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

There total 13 articles about 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1208330-99-7
ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

: 1208330-01-1
3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1161274-19-6
4-cyano-2-methylbenzoyl chloride

: 1208330-01-1
3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: ozone / dichloromethane / 1 h / -78 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

5.1: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

6.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

7.1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

8.1: toluene / Reflux

9.1: hydrogen / tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

10.1: water; lithium hydroxide / methanol / 3 h / 20 °C

With manganese(IV) oxide; n-butyllithium; water; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ozone; diisopropylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; dimethyl sulfoxide; toluene; mineral oil; 8.1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208331-46-7
ethyl 3-(4-cyano-2-methylphenyl)-3-oxopropanoate

: 1208330-01-1
3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: ozone / dichloromethane / 1 h / -78 °C

3.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

4.1: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

5.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

6.1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

7.1: toluene / Reflux

8.1: hydrogen / tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

9.1: water; lithium hydroxide / methanol / 3 h / 20 °C

With manganese(IV) oxide; water; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ozone; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; dimethyl sulfoxide; toluene; mineral oil; 7.1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086