ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

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Chemical Name:ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate
CAS No.:1208330-99-7
Molecular Formula:C₂₄H₂₅ClN₂O₄
Molecular Weight:440.927
Hs Code.:

Synonyms:ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

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Chemical Property of ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

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Technology Process of ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

There total 13 articles about ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1208330-97-5
(E)-ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)acrylate

: 1208330-99-7
ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

Guidance literature:: With hydrogen; In tetrahydrofuran; at 20 ℃; for 2h; under 760.051 Torr;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1161274-19-6
4-cyano-2-methylbenzoyl chloride

: 1208330-99-7
ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: ozone / dichloromethane / 1 h / -78 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

5.1: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

6.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

7.1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

8.1: toluene / Reflux

9.1: hydrogen / tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

With manganese(IV) oxide; n-butyllithium; water; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ozone; diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; dimethyl sulfoxide; toluene; mineral oil; 8.1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208331-48-9
ethyl 2-(4-cyano-2-methylbenzoyl)pent-4-enoate

: 1208330-99-7
ethyl 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-chloro-2-methoxyphenyl)-1H-pyrrol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: ozone / dichloromethane / 1 h / -78 °C

2: pyridinium p-toluenesulfonate / ethanol / 6 h / 50 °C

3: water; dihydrogen peroxide; sodium hydroxide / dimethyl sulfoxide / 4 h / 20 °C

4: diisobutylaluminium hydride / toluene / 2 h / -78 °C

5: manganese(IV) oxide / dichloromethane / 48 h / Reflux

6: toluene / Reflux

7: hydrogen / tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

With manganese(IV) oxide; water; hydrogen; dihydrogen peroxide; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; ozone; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; toluene; 6: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086