2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one

Base Information

• Chemical Name: 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one
• CAS No.: 1053246-07-3
• Molecular Formula: C₂₁H₂₃FO₅
• Molecular Weight: 374.409

Synonyms:2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one

Chemical Property of 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one

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Technology Process of 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one

There total 1 articles about 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethanol (1053246-05-1) → 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one (1053246-07-3)

Guidance literature:

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tetasy.2008.06.007

Reference yield: 97.0%

2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethan-1-one (1053246-07-3) + 4-flourophenylmagnesium bromide (352-13-6) → 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-(1S)-1-(2-fluorophenyl)-1-(4-fluorophenyl)ethanol (1053246-09-5) + 2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)ethanol (1053246-15-3)

Guidance literature:

With magnesium bromide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tetasy.2008.06.007

upstream raw materials:

2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-1-(2-fluorophenyl)ethanol

Downstream raw materials:

2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-(1S)-1-(2-fluorophenyl)-1-(4-fluorophenyl)ethanol

2-{[(R)-[(4R)-2,2-dimethyl-[1,3]dioxolan-4-yl]-(4-methoxyphenyl)methyl]oxy}-(1R)-1-(2-fluorophenyl)-1-(4-fluorophenyl)ethanol

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