N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]

Base Information

Chemical Name:N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]
CAS No.:1314789-15-5
Molecular Formula:C₂₂H₂₆Br₂N₂O₄S₂
Molecular Weight:606.399
Hs Code.:

Synonyms:N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]

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Chemical Property of N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]

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Technology Process of N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]

There total 4 articles about N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 51-85-4
2,2'-dithio-bis[ethylamine]

: 20146-10-5
3-(3-bromo-4-hydroxyphenyl)propanoic acid

: 1314789-15-5
N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jm2016182

Reference yield:

: 5597-50-2
3-(4-hydroxyphenyl)propionic acid methyl ester

: 1314789-15-5
N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 5.25 h / 25 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 23 °C / Inert atmosphere

3.1: N-hydroxyphthalimide; dicyclohexyl-carbodiimide / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere

3.2: 12 h / 25 °C / Inert atmosphere

With N-Bromosuccinimide; N-hydroxyphthalimide; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.026

Reference yield:

: 60553-38-0
methyl 3-(3-bromo-4-hydroxy-phenyl)propionate

: 1314789-15-5
N,N'-[2,2'-disulfanediylbis(ethane-2,1-diyl)]bis[3-(3-bromo-4-hydroxyphenyl)propanamide]

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 23 °C / Inert atmosphere

2.1: N-hydroxyphthalimide; dicyclohexyl-carbodiimide / 1,4-dioxane / 2 h / 25 °C / Inert atmosphere

2.2: 12 h / 25 °C / Inert atmosphere

With N-hydroxyphthalimide; dicyclohexyl-carbodiimide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/j.bmc.2010.12.026