(S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide

Base Information

• Chemical Name: (S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide
• CAS No.: 887147-35-5
• Molecular Formula: C₁₆H₂₄BNO₃
• Molecular Weight: 289.182
• Mol file: 887147-35-5.mol

Synonyms:(S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide

Chemical Property of (S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide

There total 4 articles about (S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanamine (1260955-16-5) + acetic anhydride (108-24-7) → (S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide (887147-35-5)

Guidance literature:

With pyridine; In ethyl acetate; at 30 ℃; for 12h;

DOI:10.1016/j.tetasy.2013.10.004

Reference yield:

C8H12BNO2 → (S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide (887147-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / Heating

2: pyridine / ethyl acetate / 12 h / 30 °C

With pyridine; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.tetasy.2013.10.004

Reference yield:

2,3-dimethyl-2,3-butane diol (76-09-5) → (S)-N-(1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)acetamide (887147-35-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 40 °C

2: 2-aminopropanoic acid; pyridoxal 5'-phosphate; NADP; ammonium formate; Candida boidinii formate dehydrogenase; alanine dehydrogenase; Chromobacterium violaceum ω-transaminase / aq. phosphate buffer; dimethyl sulfoxide / 24 h / 30 °C / Enzymatic reaction

3: pyridine / ethyl acetate / 12 h / 30 °C

With pyridine; Candida boidinii formate dehydrogenase; 2-aminopropanoic acid; alanine dehydrogenase; pyridoxal 5'-phosphate; Chromobacterium violaceum ω-transaminase; ammonium formate; NADP; In tetrahydrofuran; aq. phosphate buffer; dimethyl sulfoxide; ethyl acetate;

DOI:10.1016/j.tetasy.2013.10.004

upstream raw materials:

(S)-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanamine

acetic anhydride

2,3-dimethyl-2,3-butane diol

1-[3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethanone

Downstream raw materials:

(S)-N-(1-(3-bromophenyl)ethyl)acetamide

(S)-3-(1-acetamidoethyl)phenylboronic acid