{5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone

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Chemical Name:{5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone
CAS No.:1014702-30-7
Molecular Formula:C₃₁H₄₁N₅O₂
Molecular Weight:515.699
Hs Code.:

Synonyms:{5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone

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Chemical Property of {5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone

There total 7 articles about {5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 4524-93-0
Cyclopentanecarboxylic acid chloride

: 1014702-57-8
3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

: 1014702-30-7
{5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone

Guidance literature:: 3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; at 20 ℃; for 0.5h;

Cyclopentanecarboxylic acid chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

: 1014702-81-8
(5-benzyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

: 1014702-30-7
{5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium formate / palladium on activated charcoal / methanol / 8 h / Heating / reflux

2.1: acetic acid / dichloromethane / 12 h / 0 - 20 °C

3.1: trifluoroacetic acid / 0.5 h / 20 °C

3.2: 12 h / 0 - 20 °C

With ammonium formate; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

: C₁₉H₂₇NO₄

: 1014702-30-7
{5-[3-(1-cyclopentanecarbonyl-azetidin-3-yl)-3-phenyl-propyl]-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl}-(4,6-dimethyl-pyrimidin-5-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane / 12 h / -78 - 20 °C

2.1: commercial bleach; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 4 h / 0 - 20 °C

3.1: acetic acid / dichloromethane / 12 h / 0 - 20 °C

4.1: trifluoroacetic acid / 0.5 h / 20 °C

4.2: 12 h / 0 - 20 °C

With commercial bleach; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; trifluoroacetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In dichloromethane; water;