3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester
CAS No.:1014702-57-8
Molecular Formula:C₃₀H₄₁N₅O₃
Molecular Weight:519.687
Hs Code.:

Synonyms:3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

There total 8 articles about 3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 135865-78-0
(4,6-dimethyl-pyrimidin-5-yl)-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone

: C₁₇H₂₃NO₃

: 1014702-57-8
3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With acetic acid; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield:

: 1014702-81-8
(5-benzyl-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(4,6-dimethyl-pyrimidin-5-yl)-methanone

: 1014702-57-8
3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / palladium on activated charcoal / methanol / 8 h / Heating / reflux

2: acetic acid / dichloromethane / 12 h / 0 - 20 °C

With ammonium formate; acetic acid; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

: C₁₉H₂₇NO₄

: 1014702-57-8
3-{3-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-1-phenyl-propyl}-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane / 12 h / -78 - 20 °C

2: commercial bleach; sodium hydrogencarbonate / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 4 h / 0 - 20 °C

3: acetic acid / dichloromethane / 12 h / 0 - 20 °C

With commercial bleach; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In dichloromethane; water;