2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde

Base Information

Chemical Name:2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde
CAS No.:1584233-76-0
Molecular Formula:C₂₀H₁₉N₃O₅
Molecular Weight:381.388
Hs Code.:

Synonyms:2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde

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Chemical Property of 2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde

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Technology Process of 2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde

There total 2 articles about 2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 5392-10-9
2-bromo-4,5-dimethoxybenzaldehyde

: 400877-60-3
1-[(4-methylphenyl)methyl]-4-nitro-1H-pyrazole

: 1584233-76-0
2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl-formamide; at 120 ℃; regioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/jo4025418

Reference yield:

: 104-81-4
4-Methylbenzyl bromide

: 1584233-76-0
2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere; Schlenk technique

2: potassium carbonate; copper(l) iodide; Trimethylacetic acid; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 120 °C / Schlenk technique; Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo4025418

Reference yield: 90.0%

: 1584233-76-0
2-(1-(4-methylbenzyl)-4-nitro-1H-pyrazol-5-yl)-4,5-dimethoxybenzaldehyde

: 1584233-87-3
1-(4-methylbenzyl)-7,8-dimethoxy-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 5h; Inert atmosphere; Schlenk technique;
DOI:10.1021/jo4025418