2-(4-tert-butylbenzoylamino)-4-amino-N-(4-methoxyphenyl)benzamide

Base Information

Chemical Name:2-(4-tert-butylbenzoylamino)-4-amino-N-(4-methoxyphenyl)benzamide
CAS No.:219493-03-5
Molecular Formula:C₂₅H₂₇N₃O₃
Molecular Weight:417.508
Hs Code.:
DSSTox Substance ID:DTXSID001142237
Nikkaji Number:J1.303.344G
ChEMBL ID:CHEMBL171170

Synonyms:CHEMBL171170;SCHEMBL5223816;AYVXSVRMUNRIML-UHFFFAOYSA-N;DTXSID001142237;2-(4-tert-butylbenzoylamino)-4-amino-N-(4-methoxyphenyl)benzamide;4-amino-2-[(4-tert-butylbenzoyl)amino]-N-(4-methoxyphenyl)benzamide;4-Amino-2-[[4-(1,1-dimethylethyl)benzoyl]amino]-N-(4-methoxyphenyl)benzamide;219493-03-5

Suppliers and Price of 2-(4-tert-butylbenzoylamino)-4-amino-N-(4-methoxyphenyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-tert-butylbenzoylamino)-4-amino-N-(4-methoxyphenyl)benzamide

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:417.20524173
Heavy Atom Count:31
Complexity:602

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)C1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)N)C(=O)NC3=CC=C(C=C3)OC

Technology Process of 2-(4-tert-butylbenzoylamino)-4-amino-N-(4-methoxyphenyl)benzamide

There total 4 articles about 2-(4-tert-butylbenzoylamino)-4-amino-N-(4-methoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 219491-93-7
2-(4-tert-butylbenzoylamino)-4-nitro-N-(4-methoxyphenyl)benzamide

: 219493-03-5
4-Amino-2-(4-tert-butyl-benzoylamino)-N-(4-methoxy-phenyl)-benzamide

Guidance literature:: With hydrogen; 10 percent Pd/C; In ethanol; acetic acid; ethyl acetate;
DOI:10.1021/jm990327e

Reference yield:

: 63480-10-4
4-nitroisatoic anhydride

: 219493-03-5
4-Amino-2-(4-tert-butyl-benzoylamino)-N-(4-methoxy-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / toluene / 5 h / Heating

2: 77 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

3: 61 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol; acetic acid

With pyridine; hydrogen; 10 percent Pd/C; In ethanol; dichloromethane; acetic acid; ethyl acetate; toluene; 1: Ring cleavage / 2: Acylation / 3: Reduction;
DOI:10.1021/jm990327e

Reference yield:

: 104-94-9
4-methoxy-aniline

: 219493-03-5
4-Amino-2-(4-tert-butyl-benzoylamino)-N-(4-methoxy-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / toluene / 5 h / Heating

2: 77 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

3: 61 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol; acetic acid

With pyridine; hydrogen; 10 percent Pd/C; In ethanol; dichloromethane; acetic acid; ethyl acetate; toluene; 1: Ring cleavage / 2: Acylation / 3: Reduction;
DOI:10.1021/jm990327e