Technology Process of C16H20N2O3
There total 5 articles about C16H20N2O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl (2-(butylamino)-2-oxoethyl)carbamate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 6h;
C10H8O3;
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/jo300063u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere
1.2: pH 4
2.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C
2.2: 12 h / 20 °C / Inert atmosphere
With
lithium hydroxide monohydrate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo300063u
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere
3.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 20 °C / Inert atmosphere
3.2: pH 4
4.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C
4.2: 12 h / 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jo300063u
