cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

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Chemical Name:cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide
CAS No.:1205682-39-8
Molecular Formula:C₁₈H₁₈N₄O₂
Molecular Weight:322.367
Hs Code.:

Synonyms:cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

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Technology Process of cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

There total 2 articles about cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1205683-27-7
N-(8-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide

: 22237-13-4
(4-ethoxyphenyl)boronic acid

: 1205682-39-8
cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 140 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/jm501262q

Reference yield:

: 1124382-72-4
8-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-ylamine

: 1205682-39-8
cyclopropanecarboxylic acid [8-(4-ethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 5 - 20 °C

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 140 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; triethylamine; In 1,4-dioxane; water; acetonitrile;
DOI:10.1021/jm501262q