(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

Base Information

Chemical Name:(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one
CAS No.:886978-75-2
Molecular Formula:C₃₇H₅₂N₄O₆SSi₂
Molecular Weight:737.08
Hs Code.:

(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

Synonyms:(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

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Chemical Property of (4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

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Technology Process of (4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

There total 1 articles about (4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)methylmethanesulfonate

: (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)methyl methanesulfonate

: 141629-19-8
(4S)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one

: 886978-74-1
(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({5-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl}methyl)pyrrolidin-2-one

: 886978-75-2
(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

Guidance literature:: (4S)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

(6-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl)methylmethanesulfonate; (5-[4-(ethylsulfonyl)phenoxy]-2-(pyridin-2-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl)methyl methanesulfonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 886978-74-1
(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({5-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl}methyl)pyrrolidin-2-one

: 886978-75-2
(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

: (4S)-1-({5-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1H-benzimidazol-6-yl}methyl)-4-hydroxypyrrolidin-2-one

Guidance literature:: (4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({5-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl}methyl)pyrrolidin-2-one; (4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one; With water; trifluoroacetic acid; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 886978-74-1
(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({5-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl}methyl)pyrrolidin-2-one

: 886978-75-2
(4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one

: (4S)-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)-4-hydroxypyrrolidin-2-one

: (4S)-1-({5-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl}methyl)-4-hydroxypyrrolidin-2-one

Guidance literature:: (4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({5-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-6-yl}methyl)pyrrolidin-2-one; (4S)-4-{[t-butyl(dimethyl)silyl]oxy}-1-({6-[4-(ethylsulfonyl)phenoxy]-2-(2-pyridinyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-5-yl}methyl)pyrrolidin-2-one; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;

pH=6; Aqueous phosphate buffer;