(4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pyrrolidinone

Base Information

Chemical Name:(4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pyrrolidinone
CAS No.:141629-19-8
Molecular Formula:C10H21NO2Si
Molecular Weight:215.368
Hs Code.:2933790090
Mol file:141629-19-8.mol

Synonyms:2-Pyrrolidinone,4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (S)-;(4S)-4-[(tert-Butyldimethylsilyl)oxy]-2-pyrrolidinone;

Suppliers and Price of (4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-4-(tert-Butyldimethylsilyloxy)pyrrolidin-2-one
50mg
$ 45.00

Crysdot
(S)-4-((tert-Butyldimethylsilyl)oxy)pyrrolidin-2-one 95+%
5g
$ 677.00

Chemenu
(S)-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-one 95%
5g
$ 640.00

AK Scientific
(S)-4-(t-Butyldimethylsilyloxy)pyrrolidin-2-one
5g
$ 1011.00

Total 7 raw suppliers

Chemical Property of (4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pyrrolidinone

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
Refractive Index:1.455
Boiling Point:289.999 °C at 760 mmHg
Flash Point:129.187 °C
PSA：38.33000
Density:0.965g/cm³
LogP:2.22550

Purity/Quality:

98%min ^*data from raw suppliers

(S)-4-(tert-Butyldimethylsilyloxy)pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pyrrolidinone

There total 3 articles about (4S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 68108-18-9,96820-00-7
(4S)-4-hydroxypyrrolidin-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 141629-19-8
(4S)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 40 ℃;
DOI:10.1021/jo901790g

Reference yield: 65.0%

: 237768-62-6
(S)-4-azido-3-(tert-butyldimethylsiloxy)butyraldehyde

: 141629-19-8
(4S)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one

Guidance literature:: With titanium tetrachloride; In dichloromethane; at -20 ℃; for 1h;
DOI:10.1055/s-1999-3111

Reference yield:

: 237768-61-5
ethyl (S)-4-azido-3-(tert-butyldimethylsiloxy)butanoate

: 141629-19-8
(4S)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / DIBAL / hexane / 0.25 h / -78 °C

2: 65 percent / TiCl₄ / CH₂Cl₂ / 1 h / -20 °C

With titanium tetrachloride; diisobutylaluminium hydride; In hexane; dichloromethane;
DOI:10.1055/s-1999-3111