Technology Process of benzyl (2S,5R,6R)-6-<(R)-1-(t-butyldimethylsilyloxy)ethyl>penicillanate 1,1-dioxide
There total 16 articles about benzyl (2S,5R,6R)-6-<(R)-1-(t-butyldimethylsilyloxy)ethyl>penicillanate 1,1-dioxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: BF3*OEt2 / CH2Cl2
2: BuLi / tetrahydrofuran / 0.67 h / -78 °C
3: 100 percent / Bu3SnH / AIBN / tetrahydrofuran / 2 h / 60 °C
4: imidazole / dimethylformamide / 20 h / Ambient temperature
5: m-chloroperbenzoic acid / CH2Cl2 / 2 h / Ambient temperature
With
1H-imidazole; n-butyllithium; boron trifluoride diethyl etherate; tri-n-butyl-tin hydride; 3-chloro-benzenecarboperoxoic acid;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.1887
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / Bu3SnH / AIBN / tetrahydrofuran / 2 h / 60 °C
2: imidazole / dimethylformamide / 20 h / Ambient temperature
3: m-chloroperbenzoic acid / CH2Cl2 / 2 h / Ambient temperature
With
1H-imidazole; tri-n-butyl-tin hydride; 3-chloro-benzenecarboperoxoic acid;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.1887
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / MeMgBr / tetrahydrofuran / 0.67 h / -78 °C
2: 100 percent / Bu3SnH / AIBN / tetrahydrofuran / 2 h / 60 °C
3: imidazole / dimethylformamide / 20 h / Ambient temperature
4: m-chloroperbenzoic acid / CH2Cl2 / 2 h / Ambient temperature
With
1H-imidazole; methylmagnesium bromide; tri-n-butyl-tin hydride; 3-chloro-benzenecarboperoxoic acid;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.59.1887
