4H-Imidazol-4-one,2-ethyl-1,5-dihydro-5-(1-methylethylidene)-(9CI)

Base Information

• Chemical Name: 4H-Imidazol-4-one,2-ethyl-1,5-dihydro-5-(1-methylethylidene)-(9CI)
• CAS No.: 210297-12-4
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.196
• Mol file: 210297-12-4.mol

Synonyms:4H-Imidazol-4-one,2-ethyl-1,5-dihydro-5-(1-methylethylidene)- (9CI)

Chemical Property of 4H-Imidazol-4-one,2-ethyl-1,5-dihydro-5-(1-methylethylidene)-(9CI)

Chemical Property:

• PSA: 41.46000
• LogP: 0.98300

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-Imidazol-4-one,2-ethyl-1,5-dihydro-5-(1-methylethylidene)-(9CI)

There total 1 articles about 4H-Imidazol-4-one,2-ethyl-1,5-dihydro-5-(1-methylethylidene)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl acetimidate (1070-17-3) + GlyOEt*HCl (459-73-4) → 2-ethyl-5-isopropylidene-3,5-dihydro-imidazol-4-one (210297-12-4)

Guidance literature:

With acetone;

DOI:10.1021/ja01111a011

Reference yield:

2-ethyl-5-isopropylidene-3,5-dihydro-imidazol-4-one (210297-12-4) + N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) → 2-Ethyl-5-isopropylidene-3-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,5-dihydro-imidazol-4-one

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 - 10 ℃; for 2h;

DOI:10.1248/cpb.46.777

Reference yield:

2-ethyl-5-isopropylidene-3,5-dihydro-imidazol-4-one (210297-12-4) → 2-Ethyl-5-isopropylidene-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,5-dihydro-imidazol-4-one

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butoxide / dimethylformamide / 2 h / 0 - 10 °C

2: AcOH / methanol / 2 h / Heating

With potassium tert-butylate; acetic acid; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.777

upstream raw materials:

ethyl acetimidate

GlyOEt*HCl