((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

Base Information

Chemical Name:((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate
CAS No.:1187433-92-6
Molecular Formula:C₁₅H₁₉FO₅
Molecular Weight:298.311
Hs Code.:

Synonyms:((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

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Technology Process of ((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

There total 7 articles about ((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187433-90-4
(2R,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxy-3,4-dimethyl-tetrahydrofuran-3-ol

: 98-88-4
benzoyl chloride

: 1187433-92-6
((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

: 1187433-91-5
((2R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: (2R,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxy-3,4-dimethyl-tetrahydrofuran-3-ol; With dmap; triethylamine; In dichloromethane; at 0 ℃;

benzoyl chloride; In dichloromethane; at 0 - 45 ℃;

Reference yield:

: 1187433-88-0
(2R,3S,4R)-2-((tert-butyldiphenylsilyloxy)methyl)-4-fluoro-5-methoxy-3,4-dimethyltetrahydrofuran-3-ol

: 1187433-92-6
((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 1.67 h / 0 - 20 °C

2.1: dmap; triethylamine / dichloromethane / 0 °C

2.2: 0 - 45 °C

With dmap; tetrabutyl ammonium fluoride; water; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 874638-80-9,1033394-94-3
((2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-tetrahydrofuran-2-yl)methyl benzoate

: 1187433-92-6
((2R,4R)-4-fluoro-3-hydroxy-5-methoxy-3,4-dimethyl-tetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / -10 - 0 °C

2.1: boron trifluoride diethyl etherate / 20 - 80 °C

3.1: ammonia / 36 h / 20 °C

4.1: 1H-imidazole / dichloromethane / 0 - 20 °C

5.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: diethyl ether / 4.5 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 1.67 h / 0 - 20 °C

8.1: dmap; triethylamine / dichloromethane / 0 °C

8.2: 0 - 45 °C

With 1H-imidazole; dmap; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; ammonia; water; Dess-Martin periodane; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;