N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide

Base Information

• Chemical Name: N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide
• CAS No.: 1432674-77-5
• Molecular Formula: C₁₈H₁₆F₃N₃O₄S₂
• Molecular Weight: 459.47
• Mol file: 1432674-77-5.mol

Synonyms:N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide

Chemical Property of N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide

There total 2 articles about N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,4,5-trifluorobenzene-1-sulfonyl chloride (220227-21-4) + N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine (1432674-78-6) → N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide (1432674-77-5)

Guidance literature:

N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

2,4,5-trifluorobenzene-1-sulfonyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.0c00259

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide (1432674-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / toluene / 40 h / Dean-Stark; Reflux

1.2: 5.5 h / 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - 0 °C

2.2: 3 h / -78 - 20 °C

With acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;

Reference yield: 57.0%

N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide (1432674-77-5) + (1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cyclopentan-1-ol → N-[(2,4-dimethoxyphenyl)methyl]-2,5-difluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cyclopentyl]oxy}-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide

Guidance literature:

With sodium hydride; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00259

upstream raw materials:

2,4-Dimethoxybenzaldehyde

2,4,5-trifluorobenzene-1-sulfonyl chloride

N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine