N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine

Base Information

• Chemical Name: N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine
• CAS No.: 1432674-78-6
• Molecular Formula: C₁₂H₁₅N₃O₂S
• Molecular Weight: 265.336
• Mol file: 1432674-78-6.mol

Synonyms:N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine

Chemical Property of N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine

There total 1 articles about N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-methyl-1,2,4-thiadiazol-5-amine (17467-35-5) + 2,4-Dimethoxybenzaldehyde (613-45-6) → N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine (1432674-78-6)

Guidance literature:

3-methyl-1,2,4-thiadiazol-5-amine; 2,4-Dimethoxybenzaldehyde; With piperidine; In toluene; for 7h; Reflux;

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.0c00259

Reference yield: 79.0%

2,4,5-trifluorobenzene-1-sulfonyl chloride (220227-21-4) + N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine (1432674-78-6) → N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide (1432674-77-5)

Guidance literature:

N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h;

2,4,5-trifluorobenzene-1-sulfonyl chloride; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.0c00259

Reference yield:

N-[(2,4-dimethoxyphenyl)methyl]-3-methyl-1,2,4-thiadiazol-5-amine (1432674-78-6) → N-[(2,4-dimethoxyphenyl)methyl]-2,5-difluoro-4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]-N-(1,2,4-thiadiazol-5-yl)-benzene-1-sulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C

1.2: 2 h / -78 - 20 °C

2.1: sodium hydride / 1 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; lithium hexamethyldisilazane; In tetrahydrofuran;

DOI:10.1021/acs.jmedchem.0c00259

upstream raw materials:

3-methyl-1,2,4-thiadiazol-5-amine

2,4-Dimethoxybenzaldehyde

Downstream raw materials:

N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(3-methyl-1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide