(R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole

Base Information

• Chemical Name: (R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole
• CAS No.: 872052-26-1
• Molecular Formula: C₁₆H₂₀FNO₃
• Molecular Weight: 293.338

Synonyms:(R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole

Chemical Property of (R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

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Technology Process of (R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole

There total 2 articles about (R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

[(R,R)-2-(2-fluorophenyl)-5-methyl-4,5-dihydrooxazol-4-yl]methanol (872052-25-0) + 3,4-dihydro-2H-pyran (110-87-2) → (R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole (872052-26-1)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 0.5h;

DOI:10.1021/jo051610q

Reference yield:

2-fluorobenzonitrile (394-47-8) → (R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole (872052-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 28 percent / cadmium acetate dihydrate / chlorobenzene / 16 h / Heating

2: 82 percent / p-toluenesulfonic acid / CH₂Cl₂ / 0.5 h

With cadmium(II) acetate; toluene-4-sulfonic acid; In dichloromethane; chlorobenzene;

DOI:10.1021/jo051610q

Reference yield: 63.0%

(R,R)-2-(2-fluorophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole (872052-26-1) + diphenylphosphane (829-85-6) → (R,R)-2-(2-diphenylphosphinophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole (872052-27-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1021/jo051610q

upstream raw materials:

[(R,R)-2-(2-fluorophenyl)-5-methyl-4,5-dihydrooxazol-4-yl]methanol

3,4-dihydro-2H-pyran

2-fluorobenzonitrile

Downstream raw materials:

(R,R)-2-(2-diphenylphosphinophenyl)-5-methyl-4-(tetrahydropyran-2-yloxymethyl)-4,5-dihydrooxazole

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