(S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid

Base Information

Chemical Name:(S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid
CAS No.:295321-41-4
Molecular Formula:C₃₃H₄₆N₄O₈
Molecular Weight:626.75
Hs Code.:

Synonyms:(S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid

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Technology Process of (S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid

There total 1 articles about (S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 70-26-8,25104-12-5,410523-47-6
L-ornithine

: 3674-06-4
Boc-Phe-ONSu

: 295321-41-4
(S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid

Guidance literature:: With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

Reference yield:

: 295321-41-4
(S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid

: 543-27-1
isobutyl chloroformate

: C₃₈H₅₄N₄O₁₀

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at -15 ℃; for 0.333333h;

Reference yield:

: 295321-41-4
(S)-2,5-Bis-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-pentanoic acid

: 295321-56-1
(S)-2-Amino-N-[(S)-4-((S)-2-amino-3-phenyl-propionylamino)-1-hydroxymethyl-butyl]-3-phenyl-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: NMM / tetrahydrofuran / 0.33 h / -15 °C

2: 83 percent / NaBH₄ / tetrahydrofuran; ethanol / 0.42 h / 0 - 20 °C

3: 89 percent / TFA; anisole / H₂O / 0.67 h

With 4-methyl-morpholine; sodium tetrahydroborate; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; ethanol; water; 1: Acylation / 2: Reduction / 3: amide cleavage;