4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

Base Information

Chemical Name:4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide
CAS No.:1274804-81-7
Molecular Formula:C₂₆H₃₂F₃N₇O₅S₃
Molecular Weight:675.777
Hs Code.:

4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

Synonyms:4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

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Chemical Property of 4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

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Technology Process of 4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

There total 3 articles about 4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1274804-62-4
3-[4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

: 1274804-81-7
4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

Guidance literature:: 3-[4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-3-trifluoromethanesulfonyl-benzenesulfonylamino]-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 2.5h; Inert atmosphere;

With sodium carbonate; In dichloromethane; water; pH=8;

Reference yield:

: 723286-80-4
3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

: 1274804-81-7
4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / toluene / 14.25 h / 90 °C / Inert atmosphere; Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / Inert atmosphere

2.2: pH 8

With copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 1027345-12-5
[4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide

: 1274804-81-7
4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / toluene / 14.25 h / 90 °C / Inert atmosphere; Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / Inert atmosphere

2.2: pH 8

With copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; trifluoroacetic acid; In dichloromethane; toluene;