N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Base Information

Chemical Name:N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide
CAS No.:1274804-15-7
Molecular Formula:C₄₄H₅₀ClF₃N₈O₅S₃
Molecular Weight:959.578
Hs Code.:

N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Synonyms:N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

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Chemical Property of N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

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Technology Process of N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

There total 8 articles about N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1274805-16-1
4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(7-piperidin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonyl-benzenesulfonamide

: 153850-83-0
4'-chlorobiphenyl-2-carboxaldehyde

: 1274804-15-7
N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: 4-((R)-3-morpholin-4-yl-1-phenylsulfanylmethyl-propylamino)-N-(7-piperidin-4-yl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-trifluoromethanesulfonyl-benzenesulfonamide; 4'-chlorobiphenyl-2-carboxaldehyde; With acetic acid; In methanol; for 0.5h; Inert atmosphere; Cooling with ice;

With sodium tris(acetoxy)borohydride; In methanol; at 20 ℃; for 72h;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1274804-15-7
N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 20 h / 75 °C / Inert atmosphere

2.1: acetic acid / methanol / 0.5 h / Inert atmosphere; Cooling with ice

2.2: 72 h / 20 °C

With potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; ethanol; water;

Reference yield:

: 723286-80-4
3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester

: 1274804-15-7
N-{7-[1-(4'-chlorobiphenyl-2-ylmethyl)piperidin-4-yl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-4-((R)-3-morpholino-4-yl-1-phenylsulfanylmethylpropylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / toluene / 14.25 h / 90 °C / Inert atmosphere; Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 2.5 h / Inert atmosphere

2.2: pH 8

3.1: acetic acid / methanol / 0.5 h / Inert atmosphere; Cooling with ice

3.2: 72 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

5.1: acetic acid / methanol / 0.5 h / Inert atmosphere; Cooling with ice

5.2: 72 h / 20 °C

With copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; toluene;