(γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile

Base Information

• Chemical Name: (γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile
• CAS No.: 238088-41-0
• Molecular Formula: C₂₄H₄₁BClNO₂
• Molecular Weight: 421.859

Synonyms:(γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile

Chemical Property of (γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile

Chemical Property:

Purity/Quality:

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Technology Process of (γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile

There total 3 articles about (γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(γS,4R,5R)-γ-butyl-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-butanenitrile (238088-38-5) + (dichloromethyl)lithium (2146-67-0) → (γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile (238088-41-0)

Guidance literature:

(γS,4R,5R)-γ-butyl-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-butanenitrile; (dichloromethyl)lithium; In tetrahydrofuran; at -100 ℃;

With zinc(II) chloride; In tetrahydrofuran; at 25 ℃; Further stages.;

DOI:10.1021/ol990579+

Reference yield:

(4R,5R)-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-propanenitrile (238088-34-1) → (γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile (238088-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ZnCl₂ / tetrahydrofuran / 25 °C

2.1: tetrahydrofuran / -100 °C

2.2: ZnCl₂ / tetrahydrofuran / 25 °C

With zinc(II) chloride; In tetrahydrofuran;

DOI:10.1021/ol990579+

Reference yield:

(γS,4R,5R)-γ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-butanenitrile (238088-36-3) → (γS,δS,4R,5R)-γ-butyl-δ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-pentanenitrile (238088-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -100 °C

1.2: ZnCl₂ / tetrahydrofuran / 25 °C

In tetrahydrofuran;

DOI:10.1021/ol990579+

upstream raw materials:

(γS,4R,5R)-γ-butyl-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-butanenitrile

(dichloromethyl)lithium

(4R,5R)-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-propanenitrile

(γS,4R,5R)-γ-chloro-4,5-dicyclohexyl-α-methyl-1,3,2-dioxaborolane-2-butanenitrile

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