(3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone

Base Information

Chemical Name:(3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone
CAS No.:130675-42-2
Molecular Formula:C₂₀H₂₀N₂O₃
Molecular Weight:336.39
Hs Code.:

Synonyms:(3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone

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Chemical Property of (3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone

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Technology Process of (3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone

There total 5 articles about (3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 94669-69-9
(S)-5-Methoxymethoxymethyl-1-((3R,4S)-2-oxo-1,4-diphenyl-azetidin-3-yl)-pyrrolidin-2-one

: 130675-42-2
(3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone

Guidance literature:: With hydrogenchloride; In methanol; at 55 ℃; for 2h;
DOI:10.1248/cpb.38.1601

Reference yield:

: 94615-12-0
(S)-5-(methoxymethoxy)methyl-2-pyrrolidinone

: 130675-42-2
(3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / NaH / tetrahydrofuran; dimethylformamide / 20 h / Ambient temperature

2: 79 percent / H₂ / 5percent Pd-C / ethanol / 6 h / 760 Torr / Ambient temperature

3: 63 percent / TEA, trifluoroacetic anhydride / CH₂Cl₂ / 20 h / 0 °C

4: 85 percent / 10percent aq. HCl / methanol / 2 h / 55 °C

With hydrogenchloride; TEA; hydrogen; sodium hydride; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.1601

Reference yield:

: 130675-41-1
(5S)-1-<(benzyloxycarbonyl))methyl>-5-<(methoxymethoxy)methyl>-2-pyrrolidinone

: 130675-42-2
(3R,4S)-1,4-diphenyl-3-<(5S)-5-(hydroxymethyl)pyrrolidin-2-on-1-yl>-2-azetidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / H₂ / 5percent Pd-C / ethanol / 6 h / 760 Torr / Ambient temperature

2: 63 percent / TEA, trifluoroacetic anhydride / CH₂Cl₂ / 20 h / 0 °C

3: 85 percent / 10percent aq. HCl / methanol / 2 h / 55 °C

With hydrogenchloride; TEA; hydrogen; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; ethanol; dichloromethane;
DOI:10.1248/cpb.38.1601