2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester

Base Information

• Chemical Name: 2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester
• CAS No.: 98625-45-7
• Molecular Formula: C₄₃H₅₆N₆O₁₀S
• Molecular Weight: 849.018
• Mol file: 98625-45-7.mol

Synonyms:2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester

Chemical Property of 2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester

There total 8 articles about 2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.8%

2-[2-(2-Amino-3-carbamoyl-propionylamino)-4-methyl-pentanoylamino]-3-hydroxy-propionic acid methyl ester; hydrochloride (18921-35-2) + (2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester (56678-78-5) → 2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester (98625-45-7)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 40h; Ambient temperature;

DOI:10.1007/BF00574212

Reference yield:

Boc-DL-Leu-OH (13139-15-6,53296-34-7) → 2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester (98625-45-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) C₂H₅OCOCl

2: HCl / ethyl acetate

4: 98 percent / HCl / methanol

5: 59.8 percent / (C₂H₅)3N / dimethylformamide / 40 h / Ambient temperature

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1007/BF00574212

Reference yield:

N-(tert-butoxycarbonyl)-S-triphenylmethylcysteine (1123171-13-0) → 2-(2-{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetylamino]-3-carbamoyl-propionylamino}-4-methyl-pentanoylamino)-3-hydroxy-propionic acid methyl ester (98625-45-7)

Guidance literature:

Multi-step reaction with 4 steps

1: (C₂H₅)3N / CH₂Cl₂ / 0.33 h / -20 °C

3: 1,3-dicyclohexylcarbodiimide / dioxane / 7 °C

4: 59.8 percent / (C₂H₅)3N / dimethylformamide / 40 h / Ambient temperature

With triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1007/BF00574212

upstream raw materials:

2-[2-(2-Amino-3-carbamoyl-propionylamino)-4-methyl-pentanoylamino]-3-hydroxy-propionic acid methyl ester; hydrochloride

(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester

Boc-DL-Leu-OH

N-(tert-butoxycarbonyl)-S-triphenylmethylcysteine

Downstream raw materials:

{1-[({2-Carbamoyl-1-[1-(1-hydrazinocarbonyl-2-hydroxy-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-ethylcarbamoyl}-methyl)-carbamoyl]-2-tritylsulfanyl-ethyl}-carbamic acid tert-butyl ester