(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone

Base Information

• Chemical Name: (1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone
• CAS No.: 901122-69-8
• Molecular Formula: C₂₁H₁₆ClNO₃S
• Molecular Weight: 397.882

Synonyms:(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone

Chemical Property of (1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone

Chemical Property:

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Technology Process of (1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone

There total 2 articles about (1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-indoline (496-15-1) → (1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone (901122-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Et₃N / 1,2-dichloro-ethane / 1 h / 0 - 20 °C

2: 95 percent / AlCl₃ / CH₂Cl₂ / 20 °C

With aluminium trichloride; triethylamine; In dichloromethane; 1,2-dichloro-ethane; 2: Friedel-Crafts acylation;

DOI:10.1016/j.bmcl.2005.11.099

Reference yield:

benzenesulfonyl chloride (98-09-9) → (1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone (901122-69-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / Et₃N / 1,2-dichloro-ethane / 1 h / 0 - 20 °C

2: 95 percent / AlCl₃ / CH₂Cl₂ / 20 °C

With aluminium trichloride; triethylamine; In dichloromethane; 1,2-dichloro-ethane; 2: Friedel-Crafts acylation;

DOI:10.1016/j.bmcl.2005.11.099

Reference yield: 85.0%

(1-benzenesulfonyl-2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone (901122-69-8) → (2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone (881006-07-1)

Guidance literature:

With sulfuric acid; at 90 ℃; for 0.0833333h; microwave irradiation;

DOI:10.1016/j.bmcl.2005.11.099

upstream raw materials:

1-indoline

benzenesulfonyl chloride

Downstream raw materials:

(2,3-dihydro-1H-indol-5-yl)(4-chlorophenyl)methanone

(4-chlorophenyl)(1H-indol-5-yl)methanone

(4-chloro-phenyl)-(1-methyl-1H-indol-5-yl)-methanone

5-[(4-chloro-phenyl)-imidazol-1-yl-methyl]-1H-indole

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