1-Cyclohexyl-3,4-difluoropyrrolidine

Base Information

Chemical Name:1-Cyclohexyl-3,4-difluoropyrrolidine
CAS No.:209625-81-0
Molecular Formula:C₁₀H₁₇F₂N
Molecular Weight:189.248
Hs Code.:
DSSTox Substance ID:DTXSID10697667
Mol file:209625-81-0.mol

Synonyms:DTXSID10697667;1-cyclohexyl-3,4-difluoropyrrolidine;FT-0691011

Suppliers and Price of 1-Cyclohexyl-3,4-difluoropyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(3R,4R)-1-CYCLOHEXYL-3,4-DIFLUOROPYRROLIDINE 95.00%
500MG
$ 796.95

American Custom Chemicals Corporation
(3R,4R)-1-CYCLOHEXYL-3,4-DIFLUOROPYRROLIDINE 95.00%
250MG
$ 612.15

Total 5 raw suppliers

Chemical Property of 1-Cyclohexyl-3,4-difluoropyrrolidine

Chemical Property:

Boiling Point:225.9±40.0 °C(Predicted)
PKA:6.04±0.60(Predicted)
PSA：3.24000
Density:1.07±0.1 g/cm3(Predicted)
LogP:2.24880
XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:189.13290587
Heavy Atom Count:13
Complexity:158

Purity/Quality:

97% ^*data from raw suppliers

(3R,4R)-1-CYCLOHEXYL-3,4-DIFLUOROPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)N2CC(C(C2)F)F

Technology Process of 1-Cyclohexyl-3,4-difluoropyrrolidine

There total 6 articles about 1-Cyclohexyl-3,4-difluoropyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 209625-82-1
(3S,4S)-1-cyclohexyl-3,4-bis(trifluoromethanesulfonyloxy)pyrrolidine

: 209625-81-0
(3R,4R)-1-cyclohexyl-3,4-difluoropyrrolidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1021/jo0513414

Reference yield:

: 209625-83-2
(3R,4R)-1-cyclohexyl-3,4-diacetoxypyrrolidine-2,5-dione

: 209625-81-0
(3R,4R)-1-cyclohexyl-3,4-difluoropyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / sodium borohydride; iodine / tetrahydrofuran / Heating

2: triethylamine / CH₂Cl₂ / 16 h / 20 °C

3: 42 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / 20 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; iodine; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0513414

Reference yield:

: 90304-05-5
(3S,4S)-1-cyclohexylpyrrolidine-3,4-diol

: 209625-81-0
(3R,4R)-1-cyclohexyl-3,4-difluoropyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / CH₂Cl₂ / 16 h / 20 °C

2: 42 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 20 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo0513414