2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Base Information

Chemical Name:2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide
CAS No.:1207961-32-7
Molecular Formula:C₂₁H₂₀ClF₄N₇O₂
Molecular Weight:513.882
Hs Code.:

2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Synonyms:2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

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Chemical Property of 2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

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Technology Process of 2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

There total 18 articles about 2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1046861-47-5
N-(2,2,2-trifluoroethyl)-1H-imidazole-1-carboxamide

: 1207961-60-1
4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine

: 1207961-32-7
2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 3h;

Reference yield:

: 1150617-61-0
5-chloro-2-iodo-1-methyl-3-nitrobenzene

: 1207961-32-7
2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: iron; ammonium chloride / ethanol; water / 0.5 h / Reflux

2.1: sulfuric acid; acetic acid; sodium nitrite / 0.5 h / 23 °C

2.2: Reflux

3.1: potassium carbonate / acetonitrile / 12 h / 23 °C

4.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / acetonitrile / 3 h / Reflux

5.1: boron tribromide / dichloromethane / 0.17 h / 0 °C

5.2: Cooling

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.67 h / 120 °C / Inert atmosphere; Microwave irradiation

7.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 23 °C

9.1: triethylamine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 75 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sulfuric acid; boron tribromide; iron; sodium carbonate; potassium carbonate; ammonium chloride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 6.1: Suzuki coupling;
DOI:10.1021/jm200128m

Reference yield:

: 1150617-63-2
5-chloro-2-iodo-3-methylphenylamine

: 1207961-32-7
2-amino-4-{4-chloro-2-[2-(4-fluoropyrazol-1-yl)ethoxy]-6-methylphenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2,2-trifluoroethyl)amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; acetic acid; sodium nitrite / 0.5 h / 23 °C

1.2: Reflux

2.1: potassium carbonate / acetonitrile / 12 h / 23 °C

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / acetonitrile / 3 h / Reflux

4.1: boron tribromide / dichloromethane / 0.17 h / 0 °C

4.2: Cooling

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.67 h / 120 °C / Inert atmosphere; Microwave irradiation

6.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane; methanol / 12 h / 23 °C

8.1: triethylamine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 75 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; sulfuric acid; boron tribromide; sodium carbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 5.1: Suzuki coupling;
DOI:10.1021/jm200128m