5-chloro-2-iodo-1-Methyl-3-nitrobenzene

Base Information

• Chemical Name: 5-chloro-2-iodo-1-Methyl-3-nitrobenzene
• CAS No.: 1150617-61-0
• Molecular Formula: C7H5ClINO2
• Molecular Weight: 297.47757
• Hs Code.: 2904909090
• Mol file: 1150617-61-0.mol

Synonyms:5-chloro-2-iodo-1-Methyl-3-nitrobenzene;5-Chloro-2-iodo-3-methylnitrobenzene

Chemical Property of 5-chloro-2-iodo-1-Methyl-3-nitrobenzene

Chemical Property:

• Boiling Point: 322.4±42.0 °C(Predicted)
• PSA: 45.82000
• Density: 1.962±0.06 g/cm3(Predicted)
• LogP: 3.68440
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

5-Chloro-2-iodo-1-methyl-3-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2-iodo-1-Methyl-3-nitrobenzene

There total 2 articles about 5-chloro-2-iodo-1-Methyl-3-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chloro-2-methyl-6-nitrophenylamine (62790-50-5) → 5-chloro-2-iodo-1-methyl-3-nitrobenzene (1150617-61-0)

Guidance literature:

4-chloro-2-methyl-6-nitrophenylamine; With sulfuric acid; acetic acid; sodium nitrite; at 23 ℃; for 0.5h;

With potassium iodide; In water; at 23 ℃;

DOI:10.1021/jm200128m

Reference yield:

2-Methyl-6-nitroaniline (570-24-1) → 5-chloro-2-iodo-1-methyl-3-nitrobenzene (1150617-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / methanol / 4 h / 60 °C

2.1: sulfuric acid; acetic acid; sodium nitrite / 0.5 h / 23 °C

2.2: 23 °C

With N-chloro-succinimide; sulfuric acid; acetic acid; sodium nitrite; In methanol;

DOI:10.1021/jm200128m

Reference yield: 83.0%

5-chloro-2-iodo-1-methyl-3-nitrobenzene (1150617-61-0) → 5-chloro-2-iodo-3-methylphenylamine (1150617-63-2)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; for 0.5h; Reflux;

DOI:10.1021/jm200128m

upstream raw materials:

2-Methyl-6-nitroaniline

4-chloro-2-methyl-6-nitrophenylamine

Downstream raw materials:

5-chloro-2-iodo-3-methylphenylamine

5-chloro-2-iodo-3-methylphenol

5-chloro-2-iodo-1-methoxy-3-methylbenzene

2-(4-chloro-2-methoxy-6-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

Refernces