Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Base Information

Chemical Name:Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester
CAS No.:117626-66-1
Molecular Formula:C₁₈H₂₅ClO₈S₃
Molecular Weight:501.043
Hs Code.:

Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Synonyms:Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Suppliers and Price of Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

There total 8 articles about Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117626-65-0
1-methyl-5-exo-methoxy-5-endo-(phenylthio)-6-exo-chloro-7-oxabicyclo<2.2.1>heptane-2-exo,3-exo-dimethanol

: 124-63-0
methanesulfonyl chloride

: 117626-66-1
Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/jo00262a024

Reference yield:

: 56161-48-9
2-<2-(phenylthio)ethyl>-1,3-dioxolane

: 117626-66-1
Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: N-chlorosuccinimide / CCl₄ / 3 h / 25 °C

2: potassium tert-butoxide / tetrahydrofuran / 4.5 h / 25 °C

3: 1.) sec-butyllithium / 1.) DME, cyclohexane, from -78 deg C to -40 deg C, 15 min, 2.) from -78 deg C to 0 deg C

4: d-camphorsulfonic acid / methanol / 2 h / 25 °C

5: CHCl₃ / 12 h / 25 °C

6: LiAlH₄ / tetrahydrofuran / 4 h / 0 °C

7: 80 percent / N-chlorosuccinimide / methanol / 0.25 h / 25 °C

8: triethylamine / tetrahydrofuran / 2 h / 0 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; (1S)-10-camphorsulfonic acid; potassium tert-butylate; sec.-butyllithium; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; chloroform;
DOI:10.1021/jo00262a024

Reference yield:

: 117626-71-8
(+/-)-2-<2-chloro-2-(phenylthio)ethyl>-1,3-dioxolane

: 117626-66-1
Methanesulfonic acid (1R,2S,3R,4S,5S,6S)-5-chloro-3-methanesulfonyloxymethyl-6-methoxy-1-methyl-6-phenylsulfanyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: potassium tert-butoxide / tetrahydrofuran / 4.5 h / 25 °C

2: 1.) sec-butyllithium / 1.) DME, cyclohexane, from -78 deg C to -40 deg C, 15 min, 2.) from -78 deg C to 0 deg C

3: d-camphorsulfonic acid / methanol / 2 h / 25 °C

4: CHCl₃ / 12 h / 25 °C

5: LiAlH₄ / tetrahydrofuran / 4 h / 0 °C

6: 80 percent / N-chlorosuccinimide / methanol / 0.25 h / 25 °C

7: triethylamine / tetrahydrofuran / 2 h / 0 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; (1S)-10-camphorsulfonic acid; potassium tert-butylate; sec.-butyllithium; triethylamine; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jo00262a024