methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate

Base Information

• Chemical Name: methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate
• CAS No.: 138965-80-7
• Molecular Formula: C₁₇H₁₇NO₄S
• Molecular Weight: 331.392
• Mol file: 138965-80-7.mol

Synonyms:methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate

Chemical Property of methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate

There total 1 articles about methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzenesulfonamide (98-10-2) + benzaldehyde (100-52-7) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-hydroxy-2-methylidene-3-phenylpropionate (18020-59-2) + methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate (138965-80-7)

Guidance literature:

With 3-quinuclidinol; lanthanum(lll) triflate; In isopropyl alcohol; at 20 ℃; for 23h;

DOI:10.1021/jo0158635

Reference yield: 98.0%

(E)-5-bromopenta-1,3-diene (52022-82-9) + methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate (138965-80-7) → methyl 3-[N-benzenesulfonyl-N-(penta-2,4-dienyl)amino]-2-methylene-3-phenylpropanoate (1228305-56-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jo1005087

Reference yield:

methyl α-methylene-β-[(benzenesulfonyl)amino]-3-phenylpropionate (138965-80-7) → (2S,3R)-3-Benzenesulfonylamino-2-methyl-3-phenyl-propionic acid methyl ester (138965-81-8,138982-68-0) + (2R,3R)-3-Benzenesulfonylamino-2-methyl-3-phenyl-propionic acid methyl ester (138965-81-8,138982-68-0)

Guidance literature:

With hydrogen; cycloocta-1,5-diene{1,4-bis(diphenylphosphino)butane}rhodium perchlorate; In methanol; under 22800 Torr; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4020(01)81001-2

upstream raw materials:

benzenesulfonamide

benzaldehyde

acrylic acid methyl ester

Downstream raw materials:

(2S,3R)-3-Benzenesulfonylamino-2-methyl-3-phenyl-propionic acid methyl ester

(2R,3R)-3-Benzenesulfonylamino-2-methyl-3-phenyl-propionic acid methyl ester

methyl 3-[N-benzenesulfonyl-N-(penta-2,4-dienyl)amino]-2-methylene-3-phenylpropanoate