(1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester

Base Information

• Chemical Name: (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester
• CAS No.: 185394-37-0
• Molecular Formula: C₁₈H₁₉NO₇
• Molecular Weight: 361.351

Synonyms:(1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester

Chemical Property of (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester

There total 3 articles about (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2S-(2β,3aβ,7aβ))-2,3,3a,7a-tetrahydro-3a-hydroxy-1H-indole-1,2-dicarboxylic acid 1-benzyl 2-methyl ester (185394-36-9) → (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.02,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester (185394-37-0)

Guidance literature:

With oxygen; 5,15,10,20-tetraphenylporphyrin; In dichloromethane; for 9h; Irradiation;

DOI:10.1016/0040-4020(96)00871-X

Reference yield:

(2S,3aR,6S,7aR)-1-benzyl 2-methyl 3a,6-dihydroxy-3,3a,7,7a-tetrahydro-1H-indole-1,2(2H,6H)-dicarboxylate (185394-34-7) → (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.02,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester (185394-37-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Et₃N, DMAP / CH₂Cl₂ / 1 h / 0 °C

2: 74 percent / Pd(OAc)2, Ph₃P, Et₃N / toluene / 2 h / Heating

3: 87 percent / tetraphenylporphine, O₂ / CH₂Cl₂ / 9 h / Irradiation

With dmap; palladium diacetate; oxygen; 5,15,10,20-tetraphenylporphyrin; triethylamine; triphenylphosphine; In dichloromethane; toluene;

DOI:10.1016/0040-4020(96)00871-X

Reference yield:

(2S-(2β,3aβ,6α,7aβ))-2,3,3a,6,7,7a-hexahydro-6-acetyloxy-3a-hydroxy-1H-indole-1,2-dicarboxylic acid 1-benzyl 2-methyl ester (185394-35-8) → (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.02,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester (185394-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Pd(OAc)2, Ph₃P, Et₃N / toluene / 2 h / Heating

2: 87 percent / tetraphenylporphine, O₂ / CH₂Cl₂ / 9 h / Irradiation

With palladium diacetate; oxygen; 5,15,10,20-tetraphenylporphyrin; triethylamine; triphenylphosphine; In dichloromethane; toluene;

DOI:10.1016/0040-4020(96)00871-X

upstream raw materials:

(2S-(2β,3aβ,7aβ))-2,3,3a,7a-tetrahydro-3a-hydroxy-1H-indole-1,2-dicarboxylic acid 1-benzyl 2-methyl ester

(2S,3aR,6S,7aR)-1-benzyl 2-methyl 3a,6-dihydroxy-3,3a,7,7a-tetrahydro-1H-indole-1,2(2H,6H)-dicarboxylate

(2S-(2β,3aβ,6α,7aβ))-2,3,3a,6,7,7a-hexahydro-6-acetyloxy-3a-hydroxy-1H-indole-1,2-dicarboxylic acid 1-benzyl 2-methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 185394-37-0 (1S,2R,4S,6S,7R)-6-Hydroxy-8,9-dioxa-3-aza-tricyclo[5.2.2.0^2,6]undec-10-ene-3,4-dicarboxylic acid 3-benzyl ester 4-methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send