N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester

Base Information

• Chemical Name: N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester
• CAS No.: 52498-37-0
• Molecular Formula: C₂₃H₂₉NO₅
• Molecular Weight: 399.487
• Mol file: 52498-37-0.mol

Synonyms:N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester

Chemical Property of N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester

There total 6 articles about N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-3-methylacetophenone (10024-90-5) → N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester (52498-37-0)

Guidance literature:

Multi-step reaction with 5 steps

1: AcOOH, NaOAc / acetic acid

2: (i) SOCl₂, Py, (ii) /BRN= 2043682/

3: (i) (reduction), (ii) (diazotization), (iii) I₂, aq. KI

4: Py / Heating

5: H₂, 1-isopropyl-4-methyl-benzene / Pd-C

With pyridine; peracetic acid; 4-methylisopropylbenzene; hydrogen; sodium acetate; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00250a014

Reference yield:

N-Acetyl-3.5-dicyano-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninaethylester (52498-36-9) → N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester (52498-37-0)

Guidance literature:

With 4-methylisopropylbenzene; hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00250a014

Reference yield:

N-acetyl-3,5-dinitro-L-tyrosine ethyl ester (29358-99-4) → N-acetyl-4'-methoxy-3,5,3'-trimethyl-L-thyronine ethyl ester (52498-37-0)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) SOCl₂, Py, (ii) /BRN= 2043682/

2: (i) (reduction), (ii) (diazotization), (iii) I₂, aq. KI

3: Py / Heating

4: H₂, 1-isopropyl-4-methyl-benzene / Pd-C

With pyridine; 4-methylisopropylbenzene; hydrogen; palladium on activated charcoal;

DOI:10.1021/jm00250a014

upstream raw materials:

N-Acetyl-3.5-dicyano-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninaethylester

4-methoxy-3-methylacetophenone

N-acetyl-3,5-dinitro-L-tyrosine ethyl ester

N-Acetyl-3,5-diiod-4-(4-methoxy-3-methylphenoxy)-L-phenylalaninethylester

Downstream raw materials:

3,5,3'-Trimethyl-L-thyronin