1-(4-Methoxy-3-methylphenyl)ethanone

Base Information

• Chemical Name: 1-(4-Methoxy-3-methylphenyl)ethanone
• CAS No.: 10024-90-5
• Molecular Formula: C10H12 O2
• Molecular Weight: 164.204
• Hs Code.: 2914509090
• European Community (EC) Number: 831-609-7
• DSSTox Substance ID: DTXSID20143049
• Nikkaji Number: J55.032I
• Wikidata: Q83006709
• Mol file: 10024-90-5.mol

Synonyms:10024-90-5;1-(4-methoxy-3-methylphenyl)ethanone;3'-Methyl-4'-methoxyacetophenone;4'-methoxy-3'-methylacetophenone;Ethanone, 1-(4-methoxy-3-methylphenyl)-;4-Methoxy-3-methylacetophenone;ACETOPHENONE, 4'-METHOXY-3'-METHYL-;BRN 2244910;1-(4-methoxy-3-methyl-phenyl)-ethanone;1-(4-methoxy-3-methylphenyl)ethan-1-one;AI3-10516;4-08-00-00477 (Beilstein Handbook Reference);3-Iodo-4-methoxyacetophenone;SCHEMBL195793;4 -Methoxy-3-methylacetophenone;DTXSID20143049;(4 methoxy-3-methylphenyl)-ethanone;MFCD01673307;1-(3-methyl-4-methoxyphenyl)ethanone;AKOS000346365;1-(4-methoxy-3-methylphenyl)-ethanone;AS-19671;CS-0105545;FT-0703467;EN300-118793;A897532;F2146-0685;Z415732058

Chemical Property of 1-(4-Methoxy-3-methylphenyl)ethanone

Chemical Property:

• Vapor Pressure: 0.00544mmHg at 25°C
• Melting Point: 26-26.5 °C
• Refractive Index: 1.5460 (estimate)
• Boiling Point: 274.3°Cat760mmHg
• Flash Point: 120.3°C
• PSA: 26.30000
• Density: 1.018g/cm³
• LogP: 2.20620
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 164.083729621
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Methoxy-3-methylphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)C(=O)C)OC

Technology Process of 1-(4-Methoxy-3-methylphenyl)ethanone

There total 27 articles about 1-(4-Methoxy-3-methylphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylmethoxybenzene (578-58-5) + acetic anhydride (108-24-7) → 4-methoxy-3-methylacetophenone (10024-90-5)

Guidance literature:

With lithium perchlorate; at 60 ℃; for 1.5h;

DOI:10.1016/S0040-4039(02)01368-0

Reference yield: 97.0%

2-methylmethoxybenzene (578-58-5) + acetyl chloride (75-36-5) → 4-methoxy-3-methylacetophenone (10024-90-5)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; for 2h; Inert atmosphere; Reflux;

Reference yield: 96.0%

4-hydroxy-3-methylphenyl methyl ketone (876-02-8) + methyl iodide (74-88-4) → 4-methoxy-3-methylacetophenone (10024-90-5)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

DOI:10.1016/j.tetlet.2007.07.177

upstream raw materials:

2-methylmethoxybenzene

acetic anhydride

acetyl chloride

Isopropenyl acetate

Downstream raw materials:

4-methoxy-3-methylbenzoic acid

4-hydroxy-3-methylphenyl methyl ketone

4,4,4-Trifluoro-1-(3-methyl-4-methoxylphenyl)-1,3-butanedione

1-(3'-methyl-4'-methoxyphenyl)-3-(4''-methoxyphenyl)prop-2-ene-1-one

Refernces

• 1、 Hauser, Frank M.,Ganguly, Debashis. "Synthetic Studies on Nogarol Anthracyclines. Enantioselective Total Synthesis of an Aminohydroxy Epoxybenzoxocin". . p. 1842 - 1849. Retrieved 2000.
• 2、 -. "THIADIAZINE DERIVATIVES". Page/Page column 38. . Retrieved 2020/02/06.
• 3、 Shibasaki, Kaho,Togo, Hideo. "Facile preparation of 5-alkyl-1-aryltetrazoles with arenes, acyl chlorides, hydroxylamine, and diphenylphosphoryl azide". . p. 1816 - 1830. Retrieved 2020/11/19.