tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

Base Information

Chemical Name:tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate
CAS No.:603122-38-9
Molecular Formula:C₂₃H₂₈ClNO₄
Molecular Weight:417.933
Hs Code.:

Synonyms:tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

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Chemical Property of tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

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Technology Process of tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

There total 10 articles about tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

: 24424-99-5
di-tert-butyl dicarbonate

: 603122-37-8
(7S)-7-{[(2R)-2-(4-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenol

: 603122-38-9
tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jm800222k

Reference yield:

: 2788-86-5,53649-47-1,97466-49-4,21019-51-2
(R)-2-(4-chlorophenyl)oxirane

: 603122-38-9
tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 18 h / Reflux

2: tetrahydrofuran / 12 h / 20 °C

In tetrahydrofuran; ethanol;
DOI:10.1021/jm800222k

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 603122-38-9
tert-butyl [(2R)-2-(4-chlorophenyl)-2-hydroxyethyl][(2S)-7-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: AD-mixβ; water / tert-butyl alcohol / 4 h / Cooling with ice

2: Trimethyl orthoacetate; chloro-trimethyl-silane / dichloromethane / 1 h / Cooling with ice

3: ethanol / 18 h / Reflux

4: tetrahydrofuran / 12 h / 20 °C

With Trimethyl orthoacetate; chloro-trimethyl-silane; AD-mixβ; water; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm800222k