4-BROMOQUINOLINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 4-BROMOQUINOLINE-2-CARBOXYLIC ACID
• CAS No.: 209003-46-3
• Molecular Formula: C10H6 Br N O2
• Molecular Weight: 252.067
• Hs Code.: 2933499090
• Mol file: 209003-46-3.mol

Synonyms:4-Bromoquinoline-2-carboxylicacid

Chemical Property of 4-BROMOQUINOLINE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 4.71E-07mmHg at 25°C
• Melting Point: 159-164 °C (decomp)
• Refractive Index: 1.709
• Boiling Point: 398.1°Cat760mmHg
• PKA: 3?+-.0.50(Predicted)
• Flash Point: 194.6°C
• PSA: 50.19000
• Density: 1.732g/cm³
• LogP: 2.69550
• Storage Temp.: 2-8°C

Purity/Quality:

90.0%Min ^*data from raw suppliers

4-bromoquinoline-2-carboxylicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMOQUINOLINE-2-CARBOXYLIC ACID

There total 1 articles about 4-BROMOQUINOLINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-hydroxyquinoline-2-carboxylate (24782-43-2) → 4-bromoquinoline-2-carboxylic acid (209003-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: PBr₅ / 120 °C

2: aqueous NaOH

With sodium hydroxide; phosphorus pentabromide;

DOI:10.1021/jo01167a014

Reference yield: 95.0%

4-bromoquinoline-2-carboxylic acid (209003-46-3) + (1S,2S)-trans-2-aminocyclohexanol (931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5) → 4-bromo-N-[(1S,2S)-2-hydroxycyclohexyl]quinoline-2-carboxamide (1314141-23-5)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

4-bromoquinoline-2-carboxylic acid (209003-46-3) + 4-(4-((4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethynyl)benzyl)morpholine (1244016-75-8) → C29H24N2O3

Guidance literature:

With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; acetonitrile; at 60 ℃; for 2h; Inert atmosphere;

upstream raw materials:

ethyl 4-hydroxyquinoline-2-carboxylate

Downstream raw materials:

4-bromo-N-[(1S,2S)-2-hydroxycyclohexyl]quinoline-2-carboxamide

PT-3214

merck compound 1

4-bromo-N-[(1S,2S)-2-hydroxycyclohexyl]quinoline-2-carboxamide 1-oxide

Refernces