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24782-43-2

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24782-43-2 Usage

General Description

Ethyl 4-hydroxy-2-quinolinecarboxylate is a chemical compound with the molecular formula C13H11NO3. It is commonly used as a pharmaceutical intermediate in the synthesis of various drugs, including quinoline-based compounds. This chemical is known for its potential therapeutic applications, particularly in the treatment of a range of diseases and conditions, including cancer and microbial infections. Ethyl 4-hydroxy-2-quinolinecarboxylate exhibits strong antioxidant and anti-inflammatory properties, making it a promising candidate for the development of new drugs and medical treatments. Furthermore, it has shown potential as a chelating agent for metal ions, which could be useful in various industrial and research applications.

Check Digit Verification of cas no

The CAS Registry Mumber 24782-43-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,7,8 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24782-43:
(7*2)+(6*4)+(5*7)+(4*8)+(3*2)+(2*4)+(1*3)=122
122 % 10 = 2
So 24782-43-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H11NO3/c1-2-16-12(15)10-7-11(14)8-5-3-4-6-9(8)13-10/h3-7H,2H2,1H3,(H,13,14)

24782-43-2 Well-known Company Product Price

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  • Aldrich

  • (515523)  Ethyl4-hydroxy-2-quinolinecarboxylate  96%

  • 24782-43-2

  • 515523-1G

  • 622.44CNY

  • Detail
  • Aldrich

  • (515523)  Ethyl4-hydroxy-2-quinolinecarboxylate  96%

  • 24782-43-2

  • 515523-5G

  • 2,659.41CNY

  • Detail

24782-43-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 4-hydroxyquinoline-2-carboxylate

1.2 Other means of identification

Product number -
Other names ETHYL 4-HYDROXY-2-QUINOLINECARBOXYLATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:24782-43-2 SDS

24782-43-2Relevant articles and documents

Structural evaluation and electrophysiological effects of some kynurenic acid analogs

Fehér, Evelin,Szatmári, István,Dudás, Tamás,Zalatnai, Anna,Farkas, Tamás,Orinczi, Bálint L.,Fül?p, Ferenc,Vécsei, László,Toldi, József

, (2019)

Kynurenic acid (KYNA), a metabolite of tryptophan, as an excitatory amino acid receptor antagonist is an effective neuroprotective agent in case of excitotoxicity, which is the hallmark of brain ischemia and several neurodegenerative processes. Therefore, kynurenine pathway, KYNA itself, and its derivatives came into the focus of research. During the past fifteen years, our research group has developed several neuroactive KYNA derivatives, some of which proved to be neuroprotective in preclinical studies. In this study, the synthesis of these KYNA derivatives and their evaluation with divergent molecular characteristics are presented together with their most typical effects on the monosynaptic transmission in CA1 region of the hippocampus of the rat. Their effects on the basic neuronal activity (on the field excitatory postsynaptic potentials: fEPSP) were studied in in vitro hippocampal slices in 1 and 200 μM concentrations. KYNA and its derivative 4 in both 1 and 200 μM concentrations proved to be inhibitory, while derivative 8 only in 200 μM decreased the amplitudes of fEPSPs. Derivative 5 facilitated the fEPSPs in 200 μM concentration. This is the first comparative study which evaluates the structural and functional differences of formerly and newly developed KYNA analogs. Considerations on possible relations between molecular structures and their physiological effects are presented.

Structure-activity relationships of novel iodinated quinoline-2- carboxamides for targeting the translocator protein

Blair, Adele,Stevenson, Louise,Dewar, Deborah,Pimlott, Sally L.,Sutherland, Andrew

, p. 1461 - 1466 (2013/11/19)

In an effort to develop a new SPECT imaging agent for the translocator protein (TSPO), a series of novel iodinated quinoline-2-carboxamides have been synthesised and evaluated for binding affinity using rat brain homogenates. The outcome of the biological testing in combination with HPLC determination of the physicochemical properties of these compounds directed the design of new analogues resulting in 4-(2-iodophenyl)quinoline-2-N-diethylcarboxamide, a new TSPO ligand with higher affinity than the widely used clinical imaging agent PK11195.

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