[(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester
• CAS No.: 137005-61-9
• Molecular Formula: C₂₆H₃₃N₃O₅
• Molecular Weight: 467.565

Synonyms:[(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

Chemical Property of [(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

Chemical Property:

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Technology Process of [(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester

There total 1 articles about [(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + 1-Piperonylpiperazine (32231-06-4) → [(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (137005-61-9)

Guidance literature:

With isobutyl chloroformate; Yield given. Multistep reaction; 1) THF, -15 deg C, 10 min, 2a) 2h, 0 deg C, 2b) RT, overnight;

DOI:10.1246/bcsj.64.2519

Reference yield:

[(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (137005-61-9) → (S)-2-amino-1-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-3-phenylpropan-1-one

Guidance literature:

[(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester; With acetyl chloride; In methanol; at 0 ℃;

With water; In methanol;

With ammonia; In water; ethyl acetate; pH=8 - 9;

DOI:10.1039/b915210e

Reference yield:

[(S)-2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-1-benzyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (137005-61-9) → (S)-2-Amino-1-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-3-phenyl-propan-1-one; compound with trifluoro-acetic acid

Guidance literature:

With trifluoroacetic acid; at 0 ℃; for 0.5h;

DOI:10.1246/bcsj.64.2519

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

1-Piperonylpiperazine

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