(E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

Base Information

Chemical Name:(E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile
CAS No.:476443-59-1
Molecular Formula:C₂₀H₂₁NO₄
Molecular Weight:339.391
Hs Code.:

Synonyms:(E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

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Chemical Property of (E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

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Technology Process of (E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

There total 4 articles about (E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-2-(1-Ethoxy-ethoxy)-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

: 476443-59-1
(E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃;
DOI:10.1016/S0040-4039(02)01529-0

Reference yield:

: 476443-72-8
(Z)-2-Bromo-6-methoxy-hex-2-en-4-ynoic acid ethyl ester

: 476443-59-1
(E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / DIBALH / tetrahydrofuran / -78 °C

2: 93 percent / DIEA / CH₂Cl₂ / Heating

3: 34 percent / CuI; nPrNH₂ / Pd(PPh₃)4 / toluene / 60 °C

4: p-TsOH / methanol / 20 °C

With propylamine; copper(l) iodide; diisobutylaluminium hydride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene; 3: Sonogashira cross coupling;
DOI:10.1016/S0040-4039(02)01529-0

Reference yield:

: 476443-55-7
(Z)-2-Bromo-6-methoxy-hex-2-en-4-yn-1-ol

: 476443-59-1
(E)-2-Hydroxy-10-methoxy-6-methoxymethoxymethyl-2-phenyl-dec-6-ene-4,8-diynenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / DIEA / CH₂Cl₂ / Heating

2: 34 percent / CuI; nPrNH₂ / Pd(PPh₃)4 / toluene / 60 °C

3: p-TsOH / methanol / 20 °C

With propylamine; copper(l) iodide; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; toluene; 2: Sonogashira cross coupling;
DOI:10.1016/S0040-4039(02)01529-0