2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one

Base Information

Chemical Name:2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one
CAS No.:1221184-06-0
Molecular Formula:C₁₇H₁₈BrNO₄S
Molecular Weight:412.304
Hs Code.:

Synonyms:2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one

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Chemical Property of 2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one

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Technology Process of 2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one

There total 1 articles about 2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 945720-35-4
1-(2-methoxy-4-aminophenoxy)-2-methylpropan-2-ol

: 1221184-05-9
5-bromo-3-(bromomethyl)thiophene-2-carboxylic acid

: 1221184-06-0
2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one

Guidance literature:: 1-(2-methoxy-4-aminophenoxy)-2-methylpropan-2-ol; 5-bromo-3-(bromomethyl)thiophene-2-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 2873-18-9
5-bromo-2-chlorothiophene

: 1221184-06-0
2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one

: 1221183-64-7
2-(5-chlorothiophen-2-yl)-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[2,3-c]pyrrol-6(5H)-one

Guidance literature:: With potassium acetate; bis(pinacol)diborane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dimethyl sulfoxide; at 90 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1221184-06-0
2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one

: 1692-25-7
3-pyridylboronic acid

: 76-05-1
trifluoroacetic acid

: 1221183-53-4
5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-2-pyridin-3-yl-4H-thieno[3,2-c]pyrrol-6(5H)-one trifluoroacetate

Guidance literature:: 2-bromo-5-(4-(2-hydroxy-2-methylpropoxy)-3-methoxyphenyl)-4H-thieno[3,2-c]pyrrol-6(5H)-one; 3-pyridylboronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

trifluoroacetic acid; In water;