1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid

Base Information

Chemical Name:1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid
CAS No.:1282614-01-0
Molecular Formula:C₂₇H₃₁FN₄O₄S
Molecular Weight:526.632
Hs Code.:

Synonyms:1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid

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Chemical Property of 1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid

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Technology Process of 1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid

There total 8 articles about 1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1282613-00-6
N-butyl-N-(5-(3,5-dimethyl-4-(2-oxoethoxy)phenyl)-1,3,4-thiadiazol-2-yl)-2-fluorobenzamide

: 36476-78-5
3-azetidinecarboxylic acid

: 1282614-01-0
1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid

Guidance literature:: N-butyl-N-(5-(3,5-dimethyl-4-(2-oxoethoxy)phenyl)-1,3,4-thiadiazol-2-yl)-2-fluorobenzamide; 3-azetidinecarboxylic acid; With acetic acid; In methanol; at 20 ℃; for 1h;

With methanol; sodium cyanoborohydride; at 20 ℃;

With acetic acid; In methanol; pH=3 - 4;

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 1282614-01-0
1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 5 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 20 - 110 °C / Sealed

2.2: pH 1

3.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 1.5 h / 20 °C

5.1: osmium(VIII) oxide; 4-methyl-morpholine / water; tert-butyl alcohol; tetrahydrofuran / 20 °C

5.2: 2 h / 20 °C

6.1: acetic acid / methanol / 1 h / 20 °C

6.2: 20 °C

6.3: pH 3 - 4

With 4-methyl-morpholine; osmium(VIII) oxide; water; sodium hydride; acetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 592-82-5
butyl isothiocyanate

: 1282614-01-0
1-[2-(4-{5-[butyl(2-fluorobenzoyl)amino]-1,3,4-thiadiazol-2-yl}-2,6-dimethyl-phenoxy)ethyl]azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / methanol / 10 - 15 °C

2.1: trichlorophosphate / 1,4-dioxane / 20 - 80 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 1.5 h / 20 °C

4.1: osmium(VIII) oxide; 4-methyl-morpholine / water; tert-butyl alcohol; tetrahydrofuran / 20 °C

4.2: 2 h / 20 °C

5.1: acetic acid / methanol / 1 h / 20 °C

5.2: 20 °C

5.3: pH 3 - 4

With 4-methyl-morpholine; osmium(VIII) oxide; sodium hydride; hydrazine hydrate; acetic acid; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; water; tert-butyl alcohol;