4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide

Base Information

Chemical Name:4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide
CAS No.:1637586-46-9
Molecular Formula:C₂₃H₂₈Cl₂N₄O₃
Molecular Weight:479.406
Hs Code.:

Synonyms:4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide

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Chemical Property of 4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide

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Technology Process of 4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide

There total 6 articles about 4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.2%

: 1943-83-5
2-chloroethyl isothiocyanate

: 1637586-39-0
N-(1-(4-aminobenzyl)piperidin-4-yl)-4-chloro-2-methoxybenzamide

: 1637586-46-9
4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.3390/molecules19056163

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1637586-46-9
4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 4 h / 60 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

4: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

5: dichloromethane / 20 °C

With dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; acetone;
DOI:10.3390/molecules19056163

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1637586-46-9
4-chloro-N-(1-(4-(3-(2-chloroethyl)ureido)benzyl)piperidin-4-yl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetone / 4 h / 60 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 14 h / 20 °C

4: tin(II) chloride dihdyrate / water; ethanol / 1.5 h / 80 °C

5: dichloromethane / 20 °C

With dmap; tin(II) chloride dihdyrate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; acetone;
DOI:10.3390/molecules19056163