3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

Base Information

Chemical Name:3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile
CAS No.:1416324-29-2
Molecular Formula:C₂₉H₂₉N₃O₄
Molecular Weight:483.567
Hs Code.:

Synonyms:3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

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Chemical Property of 3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

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Technology Process of 3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

There total 5 articles about 3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.7%

: 218632-01-0
3-fluoro-4-nitrobenzonitrile

: 1416324-28-1
{[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]dec-7-yl]methyl}amine

: 1416324-29-2
3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 - 40 ℃;

Reference yield:

: 1416324-26-9
(1S,4'R,5'R,6R)-6-methyl-4',5'-diphenylspiro[bicyclo[4.1.0]heptane-2,2'-[1,3]dioxolane]

: 1416324-29-2
3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide / water; methanol / 24 h / 20 °C

2: 1-methyl-pyrrolidin-2-one / 120 h / 120 - 130 °C

3: hydrazine / methanol / 2 h / Reflux

4: potassium carbonate / acetonitrile / 20 - 40 °C

With hydrogen bromide; potassium carbonate; hydrazine; In 1-methyl-pyrrolidin-2-one; methanol; water; acetonitrile;

Reference yield:

: 1416324-25-8
(2R,3R)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]dec-6-ene

: 1416324-29-2
3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: zinc; copper; iodine / diethyl ether / 1.5 h / Inert atmosphere; Reflux

2: hydrogen bromide / water; methanol / 24 h / 20 °C

3: 1-methyl-pyrrolidin-2-one / 120 h / 120 - 130 °C

4: hydrazine / methanol / 2 h / Reflux

5: potassium carbonate / acetonitrile / 20 - 40 °C

With hydrogen bromide; iodine; copper; potassium carbonate; hydrazine; zinc; In 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; water; acetonitrile;