(S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

Base Information

Chemical Name:(S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide
CAS No.:107994-53-6
Molecular Formula:C₂₈H₃₅N₅O₄*HI
Molecular Weight:633.529
Hs Code.:

Synonyms:(S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

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Chemical Property of (S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

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Technology Process of (S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

There total 9 articles about (S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 107994-49-0
(S)-2-[1-(4-Methylsulfanylcarbonimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

: 107994-53-6
(S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

Guidance literature:: With ammonium acetate; In methanol; at 60 ℃; for 3h;

Reference yield:

: 110-89-4
piperidine

: 107994-53-6
(S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

Guidance literature:: Multi-step reaction with 4 steps

1: ethyl acetate / 1 h / Ambient temperature

2: 55 percent / H₂S / pyridine; triethylamine / 72 h / Ambient temperature

3: 70 percent / acetone / 0.25 h / Heating

4: 65 percent / CH₃COONH₄ / methanol / 3 h / 60 °C

With hydrogen sulfide; ammonium acetate; In pyridine; methanol; ethyl acetate; triethylamine; acetone;

Reference yield:

: 105414-01-5,102988-94-3
Cbz-L-Pro-OCO₂-i-Bu

: 107994-53-6
(S)-2-[1-(4-Carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester; hydriodide

Guidance literature:: Multi-step reaction with 6 steps

1: TEA / ethyl acetate / 1 h, 0 deg C; 1 h, room temp.

2: 4-ethylmorpholine / ethyl acetate / 0.25 h / 0 °C

3: ethyl acetate / 1 h / Ambient temperature

4: 55 percent / H₂S / pyridine; triethylamine / 72 h / Ambient temperature

5: 70 percent / acetone / 0.25 h / Heating

6: 65 percent / CH₃COONH₄ / methanol / 3 h / 60 °C

With N-ethylmorpholine;; TEA; hydrogen sulfide; ammonium acetate; In pyridine; methanol; ethyl acetate; triethylamine; acetone;