4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide

Base Information

Chemical Name:4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide
CAS No.:188971-92-8
Molecular Formula:C₂₆H₃₄ClN₃O₄
Molecular Weight:488.027
Hs Code.:

Synonyms:4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide

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Chemical Property of 4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide

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Technology Process of 4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide

There total 3 articles about 4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 188973-67-3
6-bromo-1-(4-hydroxyphenyl)-1-hexanone

: 4-(4-amino-5-chloro-2-methoxyphenylcarbonylamino-methyl)piperidine bis hydrochloride salt

: 188971-92-8
4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 75 ℃; for 6h;
DOI:10.1016/j.bmc.2004.02.036

Reference yield:

: 22809-37-6
6-bromohexanoyl chloride

: 188971-92-8
4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: AlCl₃ / CH₂Cl₂ / 5 - 25 °C

2: 40 percent / K₂CO₃ / dimethylformamide / 6 h / 70 - 75 °C

With aluminium trichloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2004.02.036

Reference yield:

: 108-95-2,27073-41-2
phenol

: 188971-92-8
4-amino-5-chloro-N-((1-(6-(4-hydroxyphenyl)-6-oxohexyl)piperidin-4-yl)methyl)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: AlCl₃ / CH₂Cl₂ / 5 - 25 °C

2: 40 percent / K₂CO₃ / dimethylformamide / 6 h / 70 - 75 °C

With aluminium trichloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2004.02.036