4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate

Base Information

Chemical Name:4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate
CAS No.:1436428-63-5
Molecular Formula:C₁₈H₁₇N₇O₃
Molecular Weight:379.378
Hs Code.:

Synonyms:4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate

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Chemical Property of 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate

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Technology Process of 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate

There total 7 articles about 4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75-36-5
acetyl chloride

: 139180-30-6
4-[2-(7-amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)-ethyl]-phenol

: 1436428-63-5
4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 6053-32-3
N-(furan-2-ylcarbonyl)carbonohydrazonic diamide

: 1436428-63-5
4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: water / 1 h / 140 °C / 4500.45 Torr / Microwave irradiation

2: 1 h / 170 °C / Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / -5 - 20 °C

4: acetonitrile / 20 °C

5: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.070

Reference yield:

: 139181-27-4
LUF₅₄₄₃

: 1436428-63-5
4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5yl)amino)ethyl)phenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22 h / -5 - 20 °C

2: acetonitrile / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 h / 20 °C

With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2013.03.070